The axons of these neurons are bundled into roots/nerves that contain a mix of fibers with varied excitability, including low-threshold mechanosensory fibers, higher-threshold Aβ nociceptors, and Aδ fibers. Somata diameters range from 20 to 150 μm and can be categorized based on histologic staining of neurofilament density as “large-light” neurons (generally A-neurons, relaying non-noxious information) or “small-dark” neurons (generally C-neurons, relaying painful signals). The DRG (about the size of a small peanut) is an enlargement of the dorsal root that houses somata (cell bodies) of primary sensory neurons (PSNs) up to 15,000 neurons are present in each DRG at limb-innervating segmental levels. The DRG, located within the dural sheath with only a thin surrounding layer of cerebrospinal fluid (CSF), is a bilateral structure found at every vertebral level and housed within fixed bony vertebral structures (neuroforamen) as it spans the transition from the spinal cord and vertebral column to the periphery. The DRG is a critical structure in sensory transduction and modulation, including pain transmission. This review describes the anatomic and physiologic evidence supporting clinical outcomes. In recent years, the DRG has been recognized as a viable option for neuromodulation therapy electrical stimulation of primary sensory neuron somata may be an elegant solution for treating chronic pain and has generated compelling clinical findings. With an early report in 1949 describing a technique for anesthetic infiltration of the DRG, this structure has been the focus of numerous other pain relief interventions, including dorsal rhizotomy or ganglionectomy, dorsal root entry zone (DREZ) lesioning (an adjacent related neural target), conventional radiofrequency denervation, pulsed radiofrequency, and steroid injection. The role of the dorsal root ganglion (DRG) in chronic pain has long been recognized. Neuromodulation, Neurostimulation, Dorsal Root Ganglion Stimulation, DRG Stimulation, Spinal Cord Stimulation, Chronic Pain, Neuropathic Pain, Pain Management

Dorsal column stimulator complications